Axolotl's Hand2 Gene: Unlocking Human Limb Regrowth Potential

Axolotls, the 'smiling' salamanders, can regrow limbs thanks to the Hand2 gene, which activates the Shh signaling pathway post-injury. This mechanism ensures precise limb regeneration, offering insights into potential human applications.
Researchers found that Hand2, expressed on the limb's posterior side, maintains positional memory, guiding accurate regrowth. This discovery suggests that, if similar pathways exist in humans, targeted therapies could unlock new regenerative capabilities.
Intriguingly, anterior limb cells can be reprogrammed to posterior identity by Shh signals, highlighting the potential for cell reprogramming in regenerative therapies.